Clinical Biochem and Renal Function and Blood Lipid Assessment

25/10/2020 Clinical Biochem and Renal Function and Blood Lipid Assessment https://rmit.instructure.com/courses/62949/assignments/490334 1/5 Clinical Biochem and Renal Function and Blood Lipid As‐ sessment Due Sunday by 23:59 Points 84 Submitting a file upload Available 17 Oct at 0:00 - 1 Nov at 23:59 16 days Submit Assignment BIOL1181: Clinical Biochem and Renal Function and Blood Lipid Assignment - part of Assessment Task 1: Assignments Weighting: 20% final mark (word count 800 words) Due Date: Friday 30th October 23:59 DEFERRED to 23:59 Sunday 1st November Overview: In this assignment you will be asked to demonstrate your understanding and interpretive skills that relate to what you have learned in the Clinical Biochemistry module.  Whilst some of you are not Lab Med students, the skills that you learn are also important for you - particularly if you are going to look at physiology or pharmacology in the future as these skills are similar to those that you will require in those courses. Discussion with your colleagues is encouraged. By discussing/teaching concepts with/to your colleagues, then it assists you to understand. See this link (https://effectiviology.com/protege-effect-learn-by-teaching/) . However, you must submit your own work. This assignment will be submitted via Turnitin, a software that checks for similarity in words. This will give you feedback on the percentage similarity - however this can take up to 24 hours. Please submit it early to allow time for you to amend any parts that may have been copied in error.  The reason we do this is to make sure that you really do understand what you are writing - if you can't put it in your own words, then you really don't understand it. RMIT Electronic Submission of work for assessment I declare that in submitting all work for this assessment I have read, understood and agree to the content and expectations of the assessment declaration (https://www.rmit.edu.au/students/student-essentials/assessment-and- exams/assessment/assessment-declaration) . Learning Outcomes: The Course Learning Outcomes assessed by this assignment are: https://effectiviology.com/protege-effect-learn-by-teaching/ https://www.rmit.edu.au/students/student-essentials/assessment-and-exams/assessment/assessment-declaration Taksh Patel 25/10/2020 Clinical Biochem and Renal Function and Blood Lipid Assessment https://rmit.instructure.com/courses/62949/assignments/490334 2/5 CLO1: Explain key concepts in biochemistry and molecular biology CLO2: Describe and explain the principles and fundamental concepts of biochemistry and molecular biology with a focus on DNA Technologies, Hormones and Biosignaling,, Metabolism, Metabolomics and Clinical Biochemistry Assessment Criteria: You will be assessed on your ability to: Answer questions succinctly (800 words +/- 10%) Provide  scientific justification for your answers in a rational and logical manner Problem solving - provide the appropriate solution to the problem Feedback and Grades: Feedback on your assignment and your grade will be released via the 'Grades' tab on the menu at the left hand side of the page within 2 weeks of the due date.   If  you have any problems with this assignment, please contact the Course Coordinator [email protected] (mailto:[email protected])  for assistance. To help you understand what you need to answer CHECK THE RUBRIC ATTACHED to this assignment - don't forget to double check this before you submit. HERE ARE THE CASE STUDIES BIOL1181 Clin Biochem Case Studies.pdf Minimise file preview mailto:[email protected] https://rmit.instructure.com/courses/62949/files/14956628/download?wrap=1 25/10/2020 Clinical Biochem and Renal Function and Blood Lipid Assessment https://rmit.instructure.com/courses/62949/assignments/490334 3/5 Case Study Clinical Biochemistry Page 1 of 2 ZOOM CB-1 Clinical biochemistry cases; Case-1 20-year-old female with Type I Diabetes Mellitus presents to the accident and emergen department, giving a 2-day history of vomiting and abdomen pain. She is drowsy, and is deep and rapid. There is a distinctive smell from her breath. Initial biochemistry resu follows: Arterial blood gas pH 7.02 (7.35-7.45) PCO2 8 mm Hg (35-45) PO2 92 mm Hg (80-110) HCO3 7 mmol/L (23-33) Plasma Sodium 127 mmol/L (137-145) Potassium 7.0 mmol/L (3.1-4.2) Chloride 93 mmol/L (98-106) Urea 10.1 mmol/L (3.0-8.0) Creatinine 0.18 mmol/L (0.05-0.12) Glucose 41.2 mmol/L (3.5-6.4) Urine dip stick Glucose +++ 25/10/2020 Clinical Biochem and Renal Function and Blood Lipid Assessment https://rmit.instructure.com/courses/62949/assignments/490334 4/5 Criteria Ratings Pts 6.0 pts 12.0 pts 18.0 pts 3.0 pts 21.0 pts 12.0 pts Interp Clin Features Interpretation of clinical features (6 marks) 6.0 Pts Exemplary All signs & symptoms defined &/or explained in detail. All correlated to pathophysiological processes. 4.0 Pts Adequate All signs & symptoms defined &/or explained. However, the correlation to the pathophysiological processes was unclear. 2.0 Pts Needs more work No definition or explanation for signs & symptoms. No correlation to any suitable pathophysiological process. Signs and symptoms only restated. 0.0 Pts Unsatisfactory No definition or explanation for signs & symptoms. No correlation to any suitable pathophysiological process. Signs and symptoms only restated. Eval & Interp Lab Results Evaluation and interpretation of laboratory results (12 marks) 12.0 Pts Exemplary All laboratory results discussed in detail and with clear analytical and logical thought processes. 8.0 Pts Adequate All laboratory results were discussed however, key results have been misinterpreted. 4.0 Pts Needs more work Laboratory results discussed, however key results were omitted from the analysis. 0.0 Pts Unsatisfactory No discussion of laboratory results. Laboratory results only restated. Data Analysis Analysis of Data leading to Provisional diagnosis (PD) (18 marks) 18.0 Pts Exemplary PD thoroughly discussed demonstrating broad and coherent knowledge throughout case with relevant justification. 12.0 Pts Adequate PD discussed throughout case with justification for the selection, however, relevant laboratory or clinical data has been omitted. 6.0 Pts Needs more work Analysis of the data is attempted but is incomplete or off-track. 0.0 Pts Unsatisfactory No relevant analysis or justification. PD Correct Provisional Diagnosis selected (3 marks) 3.0 Pts Exemplary Correct PD selected 2.0 Pts Adequate A relevant diagnosis was selected for the PD. 0.0 Pts Unsatisfactory Incorrect PD was selected Answers to Questions Correct answer provided for the given questions (21) 21.0 Pts Exemplary All the questions (including calculations) are answered and discussion correctly with adequate details 14.0 Pts Adequate All the questions (including calculations) are answered correctly, however discussions are inadequate with lacking attention to the details 7.0 Pts Needs more work Some questions are answered, with flaws in accuracy, lack of attention to the details, inadequate discussion 0.0 Pts Unsatisfactory No question is answered correctly Aetiology and Pathophys Aetiology & pathophysiology of PD (12 marks) 12.0 Pts Exemplary Aetiology & pathophysiology of PD accurately, concisely and logically described. 8.0 Pts Adequate Aetiology & pathophysiology of PD described however, key concepts are described unclearly, or the information presented is repetitive. 4.0 Pts Needs more work Aetiology & pathophysiology of PD described but significant features have been omitted. 0.0 Pts Unsatisfactory Aetiology & pathophysiology of PD was not described or an unrelated diagnosis was described. 25/10/2020 Clinical Biochem and Renal Function and Blood Lipid Assessment https://rmit.instructure.com/courses/62949/assignments/490334 5/5 Total points: 84.0 Criteria Ratings Pts 12.0 pts Communication Communication Style (12 marks) 12.0 Pts Exemplary Well-developed communication skills by effectively communicating scientific concepts clearly, concisely and logically. 800 words ± 10% (for the two cases combined) (excluding tables and figures) 8.0 Pts Adequate Intermediate communication skills demonstrated by a mixture of styles in the various sections of this case study. 11-15% over or under 800 words (for the two cases combined) (excluding tables and figures) 4.0 Pts Needs more work Low level communication skills demonstrated but sections with illogical flow and/or long- winded and circuitous explanations. 16-20% over or under 800 words (for the two cases combined) (excluding tables and figures) 0.0 Pts Unsatisfactory Poor/no communication skills demonstrated by illogical flow and/or long-winded and circuitous explanations. 20% over or under 800 words (for the two cases combined) (excluding tables and figures) RMIT Classification: Trusted CB-1 Clinical biochemistry cases; Case-1 20-year-old female with Type I Diabetes Mellitus presents to the accident and emergency department, giving a 2-day history of vomiting and abdomen pain. She is drowsy, and her breathing is deep and rapid. There is a distinctive smell from her breath. Initial biochemistry results are as follows: Arterial blood gas pH 7.02 (7.35-7.45) PCO2 8 mm Hg (35-45) PO2 92 mm Hg (80-110) HCO3 7 mmol/L (23-33) Plasma Sodium 127 mmol/L (137-145) Potassium 7.0 mmol/L (3.1-4.2) Chloride 93 mmol/L (98-106) Urea 10.1 mmol/L (3.0-8.0) Creatinine 0.18 mmol/L (0.05-0.12) Glucose 41.2 mmol/L (3.5-6.4) Urine dip stick Glucose +++ Ketones +++ 1. Describe the acid base disturbance. 2. Calculate the anion gap and comment on its significance. 3. Calculate the osmolality and comment on its significance. 4. List two potential reasons for the raised potassium result. 5. Interpret the pathology results and suggest a provisional diagnosis. RMIT Classification: Trusted Case-2 A 55-year-old male, presented with chest heaviness, increased frequency of urination with the history of hypertension. His lifestyle is very sedentary and in physical examination he showed to be obese (height 165 cm, weight 102 kg, BMI of 37.5 kg/m2). Biochemistry results are as follows: Plasma Results Reference Intervals Sodium 128 mmol/L (135-145) Potassium 5.0 mmol/L (3.5-4.5) Chloride 91 mmol/L (95-108) Urea 31.2 mmol/L (3.0-8.0) Creatinine 2.8 mmol/L (0.05-0.12) Glucose 12.1 mmol/L (3.5-6.4) Triglyceride 3.5 mmol/L (<2.0) total-chol="" 7.2="" mmol/l=""><4.0) ldl-chol="" 3.5="" mmol/l=""><2.0) hdl-chol 0.4 mmol/l (≥1.0) ast 65 u/l (5 – hdl-chol="" 0.4="" mmol/l="" (≥1.0)="" ast="" 65="" u/l="" (5="">