cHi expert, 1.Can you explain patho - Influenza viruses infect broncho-epithelial cells and how COPD is get worse by increasing phosphoinositide-3-kinase (PI3K) activity ....how PI3K-p110α isoform ??...

cHi expert,

1.Can you explain patho - Influenza viruses infect broncho-epithelial cells and how COPD is get worse by increasing phosphoinositide-3-kinase (PI3K) activity ....how PI3K-p110αisoform?? can you just use brief sentence . talk key point and in depth ....about how

2.How cigarette smoke trouble the aging of lung cells, through oxidative stress, casue COPD progression., Can you explain more details of  oxidative stress in precise stentece ....as well tahnks so much

3. Hepatic congestion and peripheral oedema happen due towhat kind of
bloodcannot enter the lungs and so returns to the venous system, .....