Burkitt lymphoma is a B-cell lymphoma that results from the t(14;18)(q32;q21) translocation (32nd section of the long arm or “q” on chromosome 14 translocated upon q21 on chromosome 18).This translocation juxtaposes the site where immunoglobulin heavy-chain genes are found next to the bcl-2 locus (on 18q21).What step in the pathogenesis of this cancer is NOT likely to occur?
A. Chronic infection promotes B-cell differentiation into antibody-secreting plasma cells.
B. A plasma cell with the t(14;18) translocation is stimulated to transcribe the immunoglobulin heavy-chain locus in the attempt to produce antibodies.
C. Bcl-2 is instead transcribed and translated to high levels of bcl-2 protein in the cytoplasm.
D. The overabundance of bcl-2 gene product promotes uncontrolled cellular proliferation of that transformed cell.
E. The bcl-2 gene product in excess forms bcl-2 homodimers (bound pairs of bcl-2), producing an antiapoptotic signal that promotes cell survival.
Already registered? Login
Not Account? Sign up
Enter your email address to reset your password
Back to Login? Click here