B440 Sp20 Exam 3: Immune System Take-Home Exam: 40pts. Complete each question below. 1. Bobby and Natasha are studying for an exam on the body’s defense system. Natasha insists that the action of...

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B440 Sp20 Exam 3: Immune System Take-Home Exam: 40pts. Complete each question below. 1. Bobby and Natasha are studying for an exam on the body’s defense system. Natasha insists that the action of dendritic cells is part of the nonspecific second line of defense, but Bobby insists that it is part of a specific immune response in the third line of defense. How would you explain to them that they are both correct? Use the following in your response and spell out the abbreviations: TLR, PAMP, MHC, APC, TH (8 pts) 2. COVID-19 infects lung airway epithelial cells. Using what you know of the immune system (i.e. do not go outside of the textbook/lecture slides), describe the actions of the immune response from initial injury/inflammation to the activation and effector function of the Cell Mediated Immune Response. Decide which types of cells will likely be activated during this infection. Describe and/or diagram the process of inflammation, antigen presentation, and T cell activation and response. (10 pts) 3. One current treatment for COVID-19 is injecting convalescent plasma into infected patients. The goal is the provide antibodies from someone who has recovered to someone who has not yet mounted a sufficient antibody response. Describe the process of B cell activation and response, including a discussion of the four major functions of antibodies and which class is important for each. Use the following in your response and spell out the abbreviations: Antigen, TFH, BCR, IL-4, Follicle, MHC, Plasma cell. (10 pts) 4. Explain why the destruction of CD4+ T cells is so damaging to overall adaptive immune response, as in individuals infected with HIV. Use the following in your response: Cell Mediated Immunity, Humoral Immunity, Tc, TFH, B cells, IL-2. (8 pts) 5. Compare and contrast the phagocytic action of a dendritic cell versus that of a B cell. What is the key difference and in what ways are they the same? (4 pts)