At this point, what is the leading hypothesis, what are the active alternatives, and is there a must not miss diagnosis? Given this differential diagnosis, what tests should be ordered?
Is the clinical information sufficient to make a diagnosis? If not, what other information do you need?
Have you crossed a diagnostic threshold for the leading hypothesis, cryptococcal meningitis? Have you ruled out the active alternatives? Do other tests need to be done to exclude the alternative diagnoses?
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