Assessment Task Students are required to individually choose one aim from one grant scenarios. Grant scenarios: • Anti-integrin therapy to dampen inflammation and reduce scar formation? • Iscomatrix...

Assessment Task
Students are required to individually choose one aim from one grant scenarios.
Grant scenarios:
• Anti-integrin therapy to dampen inflammation and reduce scar formation?
• Iscomatrix as a vaccine adjuvant to protect against genital tract chlamydial infections
Oral Presentation: As a group students need to prepare a 3 minute introduction with visual aids for
the grant proposal (as a group nominate one member to present) outlining the background and
significance of their grant proposal. For each aim in the proposal, each student will present a short
5 min presentation with visual aids outlining the background scientific information relating to the
aim and the experimental design proposed to answer the aim. This will include ethical
considerations, experimental controls and equipment required for the planned experiment.
Following your oral presentation, the review panel will ask questions on your experimental rationale
and provide comments on your proposal and presentation.
Group work: Each student will fill out a group work survey rating their own (space 1) and the other
group member participation and submit to AIC following presentations.
Referencing: Only references from refereed journals may be cited. Material from textbooks, reviews
and web pages cannot be cited although they may provide very helpful background information to
help you get a feel for your topic. Special care should be taken to ensure that references refer to
the original report of the fact being reported. You are reminded that information found in the
Introduction section of a scientific paper is NOT derived from that paper but from earlier work.
There is no minimum or maximum reference list.
Project Aims
Aim 1: Identify the immune specific integrins expressed on the surface of blood-derived
monocytes isolated from normal and burn patient patient blood in vitro.
Aim 2: Determine the immune specific integrins associated with migration of human
monocytes isolated from normal and burn patient paitent blood through the endothelium in
vitro.
Aim 3: Determine if early Scarless treatment reduce scarring outcomes in a mouse burn
wound mode in vivo.
Aim 4: Using specific function-blocking integrin antibodies (identified in aim 2) determine the
mechanisms used by scarless in vivo to improve healing and reduce scar formation.