Antidepressants A study compared the effectiveness of several antidepressants by examining the experiments in which they had passed the FDA requirements. Each of those experiments compared the active drug with a placebo, an inert pill given to some of the subjects. In each experiment some patients treated with the placebo had improved, a phenomenon called the placebo effect. Patients’ depression levels were evaluated on the Hamilton Depression Rating Scale, where larger numbers indicate greater improvement. (The Hamilton scale is a widely accepted standard that was used in each of the independently run studies.) The following scatterplot compares mean improvement levels for the antidepressants and placebos for several experiments.
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