Ann is a 40-year-old woman who has a history of anxiety and depression. She has a family history of depression. Her brother, who committed suicide at age 50; her mother; and a late maternal uncle also...


Ann is a 40-year-old woman who has a history of anxiety and depression. She has a family history of depression. Her brother, who committed suicide at age 50; her mother; and a late maternal uncle also suffered from depression. Her sister has a history of anxiety and has twin boys who have histories of depression and anxiety. Ann has taken several medications to treat her depression but has had significant side effects. She tells you that she has been looking on the Internet for better treatment and has found several sites that indicate that some people with depression do not respond to the usual dose of antidepressants, and some people have significant adverse effects with the usual dose. Genetic testing is being offered on some sites to help identify individuals who have these difficulties. She tells you that she thinks she may be one of those individuals who cannot handle the usual dose of antidepressant medication and wants to have testing to find out. What inheritance pattern for depression seems to be present in Ann’s family? What type of genetic testing is Ann referring to? How would you respond to Ann’s request for genetic testing?


Nov 16, 2021
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