An extra piece. In one type of mutation leading to a form of thalassemia, the mutation of a single base (G to A) generates a new 3' 3' splice site (blue in the illustration below) akin to the normal...


An extra piece. In one type of mutation leading to a form of<br>thalassemia, the mutation of a single base (G to A) generates a new 3'<br>3' splice site (blue in the illustration below) akin to the normal one<br>(yellow) but farther upstream.<br>Normal 3' end<br>of intron<br>5' CCTATTGGTCTATTITCCACCCITAGGCTGCTG 3'<br>5' CCTATTAGTCTAIIIICCACCCTTAGGCTGCTG 3'<br>What is the amino acid sequence of the extra segment of protein<br>synthesized in a thalassemic patient having a mutation leading to<br>aberrant splicing? The reading frame after the splice site begins with<br>TCT.<br>

Extracted text: An extra piece. In one type of mutation leading to a form of thalassemia, the mutation of a single base (G to A) generates a new 3' 3' splice site (blue in the illustration below) akin to the normal one (yellow) but farther upstream. Normal 3' end of intron 5' CCTATTGGTCTATTITCCACCCITAGGCTGCTG 3' 5' CCTATTAGTCTAIIIICCACCCTTAGGCTGCTG 3' What is the amino acid sequence of the extra segment of protein synthesized in a thalassemic patient having a mutation leading to aberrant splicing? The reading frame after the splice site begins with TCT.

Jun 11, 2022
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