According to a study published in the Cardiovascular Diabetology Journal, 2013, 78 patients out of which, at least 1 experienced MACE, major adverse cardiovascular events, incident, out of which 40...

According to a study published in the Cardiovascular Diabetology Journal, 2013, 78 patients out of which, at least 1 experienced MACE, major adverse cardiovascular events, incident, out of which 40 patients in the sitagliptin group and the 38 in the non-exposed group. The exposure-adjusted incidence rate was 0.65 per 100 patient-years in the sitagliptin group and 0.74 in the non-exposed group (incidence rate ratio = 0.83 [95% confidence interval (CI): 0.53, 1.30]). The exposure-adjusted incidence rates per 100 patient-years were 0.65 in the sitagliptin group and 0.74 in the non-exposed group (adjusted incidence rate ratio = 0.83 [95% CI: 0.53, 1.30]) For cardiovascular-related deaths, there were 12 in the sitagliptin group compared to 10 in the non-exposed group. The exposure-adjusted incidence rate for cardiovascular-related death was 0.25 per 100-patient-years for both the sitagliptin and non-exposed group (adjusted incidence rate ratio = 0.95 [95% CI: 0.40, 2.30]). In the sensitivity analysis that included all blinded exposure to sitagliptin 100 mg (n = 8,128 sitagliptin, n = 6,885 non-exposed), the cumulative patient exposure excluding studies with no events was 6,596 patient-years for the sitagliptin group and 5,114 patient-years for the non-exposed group. A total of 86 patients had at least one MACE-related event reported, with 48 in the sitagliptin group and 38 in the non-exposed group. The exposure-adjusted incidence rate was 0.73 per 100-patient-years in the sitagliptin group and 0.74 in the non-exposed group (adjusted incidence rate ratio = 0.87 [95% CI: 0.56, 1.35]).

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