A research group is studying a bacterium X that binds to mucosal cells in the lung and invades. Wildtype X has an LD 50 value of 10 bacteria when administered to mice by inhalation. Using transposon...


A research group is studying a bacterium X that binds to mucosal cells in the lung and invades. Wildtype X has an LD50
value of 10 bacteria when administered to mice by inhalation. Using transposon mutagenesis, the researchers have isolated two mutants of X that they call Xmut1 and Xmut2, both of which have LD50
values of 105 when inhaled by mice. However, in tissue culture cells, Xmut1 can invade the cells just as well as wild-type X, while Xmut2 cannot. Provide a possible explanation for these results.



May 04, 2022
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