A pregnant client asks the nurse what factors determine if a drug will transfer across the placenta. The nurse s response will be based on which of the following principles? 1. Highly lipid-soluble...

A pregnant client asks the nurse what factors determine if a drug will transfer across the placenta. The nurse s response will be based on which of the following principles?

1. Highly lipid-soluble drugs cross the placental membrane more easily than low lipids.

2. The lower the lipid content, the easier it crosses the placental membrane.

3. Drugs with large molecular weight pass rapidly through the placental membrane.

4. Highly protein bound drugs pass rapidly through the placental membrane.