A patient X is 60 years old male. Has been diagnosed with CKD (chronic kidney disease). He has been taking Tylenol or Indomethacin for his arthritis during last two years. Why NSAIDs (non-steroid...

A patient X is 60 years old male. Has been diagnosed with CKD (chronic kidney disease). He has been taking Tylenol or Indomethacin for his arthritis during last two years. Why NSAIDs (non-steroid anti-inflammatory drugs) do not affect GFR in patients with normal renal function and why it is not recommended for patients with reduced GFR, especially in patients with CKD?