A patient presents to the ED with acute RUQ pain, fever, nausea, and vomiting after consuming a meal with high fat content. You suspect acute cholecystitis and consider the pathophysiology of the...

A patient presents to the ED with acute RUQ pain, fever, nausea, and vomiting after consuming a meal with high fat content. You suspect acute cholecystitis and consider the pathophysiology of the illness. Which of the following is the inciting event of cholecystitis?

A. Obstruction

B. Increased production of cholesterol stones

C. Bacterial infection with gram-negative gut flora

D. Enzyme degradation of the mucosal wall

E. Schistosomes