A newly established sub-national testing and referral center for hematologic diseases is conducting screening procedure to establish the reference values for mothers and their newborns who are both...

Extracted text: A newly established sub-national testing and referral center for hematologic diseases is conducting screening procedure to establish the reference values for mothers and their newborns who are both presumed to be normal or healthy. As part of the screening procedure, hemoglobin levels and hemoglobin fractionation and quantification using high perfommance liquid chromatography (HPLC) were perfommed on the mother and her newborn infant. The mother's hemoglobin concentration was 125 g/L, and the newborn's was 210 g/L. The mother's hemoglobin fractions were quantified as 97% Hb A, 2% Hb A2, and 1% Hb F by HPLC. The newborn's results showed 88% Hb F, 10% Hb A, and 2% Hb A2. 1.


Extracted text: a. Were these hemoglobin results within expected reference intervals? b. Why were the mother's and the newborn's hemoglobin concentration so different? What is the difference between the test to determine the hemoglobin concentration and the test to analyze hemoglobin by HPLC? с.