A client will be receiving lepirudin (Refludan). Which of the following is true concerning this drug therapy? (Select all that apply.) 1. Ginger, garlic, and green tea may increase the risk of...

A client will be receiving lepirudin (Refludan). Which of the following is true concerning this drug therapy? (Select all that apply.)

1. Ginger, garlic, and green tea may increase the risk of bleeding.

2. Vitamin B12 is used to augment this drug s response.

3. Refludan is used for heparin-induced thrombocytopenia.

4. Activated partial thromboplastin time is monitored to determine effectiveness.

5. This drug is contraindicated for clients with severe hypertension.