A client is a 43-year-old G2 P1 at 16 weeks' gestation that has completed prenatal testing for chromosomal abnormalities. The results reveal the infant is a female with Down syndrome. The parents are...

A client is a 43-year-old G2 P1 at 16 weeks' gestation that has completed prenatal testing for chromosomal abnormalities. The results reveal the infant is a female with Down syndrome. The parents are seeking information about this syndrome. The nurse should tell the parents which of the following? Check all that apply.

1. Down syndrome can occur in mothers of any age.

2. Down syndrome is correlated with autosomal dominant traits carried by the parents.

3. Down syndrome is a result of autosomal recessive traits carried by the parents.

4. Down syndrome depends upon maternal prenatal care since pregnancy began.

5. Down syndrome occurs more frequently with advanced maternal age.

6. Down syndrome results from a trisomy of chromosome 21.