A client diagnosed with obsessive-compulsive disorder has been taking sertraline (Zoloft) but would like to have more energy every day. At his monthly checkup, he reports that his massage therapist...

A client diagnosed with obsessive-compulsive disorder has been taking sertraline (Zoloft) but would like to have more energy every day. At his monthly checkup, he reports that his massage therapist recommended he take St. John's wort to help his depression. The nurse should tell the client:

1. “St. John's wort is a harmless herb that might be helpful in this instance.”

2. “Combining St. John's wort with the Zoloft can cause a serious reaction called serotonin syndrome.”

3. “If you take St. John's, we'll have to decrease the dose of your Zoloft.”

4. “St. John's wort isn't very effective for depression, but we can increase your Zoloft dose.”