A 55-year-old African American female with a past medical history significant for recurrent esophageal reflux presents for her scheduled upper GI endoscopy. A biopsy of the tissue surrounding the lower esophageal sphincter reveals normal intestinal epithelial cells in place of the usual squamous cells; the cells extend to the basement membrane. What type of change has occurred?
A. No change, this is normal epithelium
B. Dysplasia
C. Metaplasia
D. Carcinoma in situ
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