A 48-year-old woman has severe chronic pain associated with cancer metastasis to the bone. She is reluctant to take opioids because she wants to remain alert to enjoy being around her family....

A 48-year-old woman has severe chronic pain associated with cancer metastasis to the bone. She is reluctant to take opioids because she wants to remain alert to enjoy being around her family. Furthermore, she is concerned about having opioids around the house because of the presence of young children in the home. Identify pharmacologic alternatives and nonpharmacologic interventions that might be appropriate. Identify the evidence base and the strength of the evidence for the use of the nonpharmacologic interventions.