A 45-year-old woman with a history of adult-onset asthma presents with microscopic hematuria, HTN, and acute renal failure as evidenced by significantly increased BUN and creatinine. Her renal biopsy reveals eosinophil infiltration in the mesangium but no evidence of Ag-Ab complex deposition on light microscopy or immunofluorescence. Serum evaluation is ANA negative but ANCA positive. What is her likely diagnosis?
A. Wegener granulomatosis
B. Churg-Strauss
C. Amyloidosis
D. Minimal change disease
E. Thin basement membrane disease
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