A 24-year-old man presents with hemoptysis and hematuria. A renal biopsy reveals crescents on light microscopy and linear IgG on immunofluorescence. What is the inciting event in the pathophysiology of the implicated disease?
A. Circulating endogenous antigens are trapped by circulating antibodies and lodge along the GBM in a linear pattern.
B. There is an autosomal dominant mutation in a component of type IV collagen in the GBM and lung endothelium.
C. Exogenous circulating antigens bind to local stationary antibodies as they pass through the glomerulus and lung endothelium.
D. Autoimmune antibodies bind to normal components of the lung and kidney endothelium.
E. The pathophysiology is unknown.
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