5. A patient you are monitoring has been on Telmisartan (Cozaar), an angiotensin receptor blocker for the man- agement of their hypertension. The drug must be metabolized by CYP2C9 or CYP3A4 from a...

5. A patient you are monitoring has been on Telmisartan (Cozaar), an angiotensin receptor blocker for the man- agement of their hypertension. The drug must be metabolized by CYP2C9 or CYP3A4 from a 5-methanol to a 5-carboxylic acid to exhibit its effects. After 2 years of successful therapy, their blood pressure suddenly in- creases. Why might this occur and what would you sug- gest as a substitute?