Microsoft Word - Sustained Drug Release for Glioblatoma Multiforme Problem # XXXXXXXXXXdocx ABE4523–BiomedicalMaterials Fall2020 ProblemStatement#2:...

2 pages (at least 1 research page and 1 reference page)


Microsoft Word - Sustained Drug Release for Glioblatoma Multiforme Problem # 2 2020.docx ABE4523–BiomedicalMaterials Fall2020 ProblemStatement#2: SustainedDrugDeliveryforGlioblastomaMultiforme Glioblastoma multiforme (GBM) is a particularly devastating cancer, the most common and most aggressive malignant primary brain tumor. It has a high incidence of recurrence, so evenwith the best,multimodal treatment average life expectancyisonly15months.TheonlysignificantchangeinthetreatmentofGBM overthepasttwodecadeswasthedevelopmentofanintracranial,implantabledrug delivery device, the Gliadel®wafer,which is used only during the initial surgical intervention.WhileGliadel®wasatfirstwellreceived,ithashadpoorsuccessand hasnotbeenpopularlyadoptedduetotherapidinitialdrugdelivery,andinability tofollow-upwithadditionaldeliveryupontumorrecurrence.Yourtaskistodevelop a sustained drug delivery vehicle capable of being reloaded in the incidence of tumor recurrence. This could be a completely novel device or a fundamental modificationofanexistingdeviceorprocedure.Yourresearchproposalislimitedto 5 pages (not including figures, tables, and references) and should include a brief backgroundof thediseaseandrisks/limitationsassociatedwithcurrenttreatment options,adetaileddescriptionofyourproposedsolutionwithajustificationforany assumptions, and an analysis of the biocompatibility and feasibility of the device. The description of your proposed solution should also include details on the therapeuticagentbeingreleasedtotreatthetumor,howthetherapeuticagentwill effectivelytreatthetumor,andthereleasekineticsofthedeliveryvehicle. http://www.pediatricneurosciences.com