1. Assume a drug exhibits a proportional drug effect which is stimulatory in nature. Derive the expression for S max the fractional stimulation from baseline. (Hint: Use the same approach as for I max...

1. Assume a drug exhibits a proportional drug effect which is stimulatory in nature. Derive the expression for S_max
the fractional stimulation from baseline. (Hint: Use the same approach as for I_max, but in opposite direction.)

2. Based on the graphs below, identify what kind of a PK-PD relationship can be assumed for this hypothetical drug

3. Hysteresis: what is the rationale for observing hysteresis in drug therapeutics?