1. A study of the potential of acrylonitrile to produce brain tumors in rats was conducted by administering the carcinogen in drinking water for 24 months. The results of the study for female rats are...


1. A study of the potential of acrylonitrile to produce brain tumors in rats was conducted by administering the carcinogen in drinking water for 24 months. The results of the study for female rats are tabulated below:

































Dose (mg/kg-day)Brain tumor incidence
01/179
0.121/90
0.362/91
1.254/85
3.656/90
10.8923/88



(a) Determine the potency factor (PF) of the dose-response relationship (assume it is linear). (Don’t forget to account for the one rat that had a brain tumor even though he wasn’t exposed to the chemical).




(b) How accurate is the linear model for this data?



Jun 08, 2022
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